Audrey Ames是一位有进取心的记者，试图从伊利诺斯州实验农场偶然发现的巨型蝗虫那里得到独家新闻。她努力拯救芝加哥，尽管军队掩盖了一切。

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本片是《沉默的羔羊》十周年纪念日推出的续集，这一集故事仍然改编自作家托马斯哈里斯的小说。　　从高度戒备的医院逃脱的汉尼拔（安东尼·霍普金斯 Anthony Hopkins 饰）恶习难改，继续寻找他